Raducanu was sent packing in the second round by Belarusian Aliaksandra Sasnovich 3-6 6-1 6-1.
The 12th seeded Briton, who had to come from a set down to beat Czech qualifier Linda Noskova in her debut match, was initially dazed by the world number 47’s attacking power.
Sasnovich was dictating the play early, moving the Briton across the court before the teenager responded in kind with some aggressive strokes herself.
After finding her feet Raducanu earned a key break to lead 4-2 and bagged the opening set via cross-court winner.
Sasnovich responded in the second set racing into a 4-0 lead.
The Belarusian, who had never made it past the second round in Paris, bagged the second with yet another break and then stood firm to fight off multiple break points early in the deciding set before breaking for a 3-1 lead when Raducanu’s forehand sailed over the line.
Raducanu, who has just started to get a taste of clay-court tennis last month could do nothing to turn the tide, especially with her ailing back.
Sasnovich did not wait long to put her out of her misery, a sizzling backhand down the line on her first match point ended the contest after two hours.
Her win over Emma Raducanu in the French Open is her second win over the Brit in the past eight months with Sasnovich having previously defeated her 6-2, 6-4 in the second round of Indian Wells last October.
Raducanu on the other hand finishes her first-ever clay-court swing with an overall 6-5 record.
Sasnovich will turn her attention to Angelique Kerber whom she faces in the third round.