Intimate links between diet, gut microbes, and health identified


An international team of scientists found associations between particular bacterial species and metabolic risk factors for conditions such as diabetes, heart disease, and obesity. They were surprised to discover that the gut microbiota — the community of microorganisms living in our intestines — was more strongly associated with a person’s risk of certain illnesses than their genetics.

The research suggests that it could be possible to create an individualized diet that adjusts the community of organisms living in a person’s gut to optimize the person’s health. The team also identified links between the food that people ate and their gut microbiota.
In particular, people who ate a diverse diet that was rich in healthful plant-based foods and healthful animal-based foods, such as oily fish, had high levels of health-promoting, “good” microbes in their gut.

“Given the highly personalized composition of each individual[‘s] microbiome, our research suggests that we may be able to modify our gut microbiome to optimize our health by choosing the best foods for our unique biology,” says Dr. Sarah Berry, a senior lecturer in the Department of Nutritional Sciences at King’s College London in the United Kingdom and one of the study’s authors.

Some of the microbes that the researchers discovered are completely new to science and have yet to be named. The research appears in Nature Medicine.
The study was a collaboration between scientists from more than 10 institutions, including King’s College; a health startup in the U.K. called ZOE; the University of Trento in Italy; and Massachusetts General Hospital and Harvard T.H. Chan School of Public Health, both in Boston, the United States. They analyzed the dietary habits of 1,098 individuals enrolled in a trial called PREDICT 1, and genetically sequenced their gut microbiota.
They also looked at molecular markers, or “biomarkers,” of metabolic and heart health in the participants’ blood samples, which were extracted either after a short period of fasting or after mealtimes. The analysis revealed statistically significant associations between gut microbes and particular nutrients, foods, and food groups.

The researchers found associations between specific bacteria, such as Prevotella copri and Blastocystis species, and healthy glucose metabolism following a meal. There were also links between the overall composition of the microbiota and a wide variety of biomarkers that reflect cardiovascular and metabolic health, including blood levels of glucose, lipids, and markers of inflammation.

“When you eat, you are not just nourishing your body, you are feeding the trillions of microbes that live inside your gut,” says one of the authors.

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