How does tooth enamel last a lifetime?

1883

Tooth enamel is the hardest substance in the human body, but, until now, no one knew how it managed to last a lifetime. The authors of a recent study conclude that enamel’s secret lies in the imperfect alignment of crystals. Using new imaging technology, scientists have unlocked the secrets of enamel.
If we cut our skin or break a bone, these tissues will repair themselves; our bodies are excellent at recovering from injury. Tooth enamel, however, cannot regenerate, and the oral cavity is a hostile environment. Every mealtime, enamel is put under incredible stress; it also weathers extreme changes in both pH and temperature.
Despite this adversity, the tooth enamel that we develop as a child remains with us throughout our days. Researchers have long been interested in how enamel manages to stay functional and intact for a lifetime.
As one of the authors of the latest study, Prof. Pupa Gilbert from the University of Wisconsin–Madison puts it, “How does it prevent catastrophic failure?”
With assistance from researchers at the Massachusetts Institute of Technology (MIT) in Cambridge and the University of Pittsburgh, PA, Prof. Gilbert took a detailed look at the structure of enamel. The team of scientists has now published the results of its study in the journal Nature Communications.
Enamel is made up of so-called enamel rods, which consist of hydroxyapatite crystals. These long, thin enamel rods are around 50 nanometers wide and 10 micrometers long. Recent research has shown that gum disease might play a part in a wide range of conditions. By using cutting edge imaging technology, the scientists could visualize how individual crystals in tooth enamel are aligned. The technique, which Prof. Gilbert designed, is called polarization-dependent imaging contrast (PIC) mapping.
Before the advent of PIC mapping, it was impossible to study enamel with this level of detail. “[Y]ou can measure and visualize, in color, the orientation of individual nanocrystals and see many millions of them at once,” explains Prof. Gilbert.
“The architecture of complex biominerals, such as enamel, becomes immediately visible to the naked eye in a PIC map.” When they viewed the structure of enamel, the researchers uncovered patterns. “By and large, we saw that there was not a single orientation in each rod, but a gradual change in crystal orientations between adjacent nanocrystals,” explains Gilbert. “And then the question was, ‘Is this a useful observation?’”

Previous articleNadeem Afzal Chan meets Qadri in Canada
Next articlePolice to lecture on children protection in schools