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Could a supplement be as effective as exercise at protecting health?

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NEW research suggests that a common dietary supplement, glucosamine, may help reduce overall death risk to a similar degree as regular exercise.
Two researchers from West Virginia University (WVU), in Morgantown, recently found that individuals who took glucosamine/chondroitin — one of the most common kinds of glucosamine supplements — on a daily basis for at least 1 year saw a 39% reduction in mortality from all causes of death and a 65% reduction in the likelihood of death from cardiovascular disease.
The study appears in the Journal of the American Board of Family Medicine.
However, Dr. Dana King, the lead author of the study and chair of Family Medicine at WVU, does not advise people to replace exercise with the supplement.
“That’s not what we suggest,” King explains. “Keep exercising. But the thought that taking a pill would also be beneficial is intriguing.”
Glucosamine/chondroitin, a combination of two natural compounds found in cartilage, is widely used to help with osteoarthritis and joint pain. During 2020–2024, the global glucosamine market is expected to grow by $229.19 million, according to Technavio, a global technology research and advisory company.
While the supplement is popular, however, several clinical trials have failed to show that it provides a significant improvement in pain.
Still, the National Institutes of Health (NIH) report that oral glucosamine supplements are “likely safe” when taken correctly by adults.
Ask the experts about the future of healthcare at a Live Town Hall hosted by our sister site, Healthline, featuring healthcare policy experts and patient advocates.
In their study, Dr. King and Jun Xiang, a health data analyst at WVU, assessed data from 16,686 adults who had completed the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2010. All of the participants were at least 40 years old.
NHANES was designed to be an ongoing assessment of the health and nutrition status of people throughout the United States. Screeners interview participants at their homes, and later, NHANES staff members perform examinations in mobile centers to collect health and nutrition data.
The WVU study was particularly interested in participants who had taken glucosamine/chondroitin for at least 365 days before their interviews. Among the participants, 658, or nearly 4%, had taken glucosamine/chondroitin for a year or longer.

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