This hospital superbug can now withstand hand sanitizer


AT hospitals around the world, staff dutifully slather on hand sanitizer to prevent the spread of infections. But now, at least one type of bacteria in hospitals appears to be growing more tolerant to alcohol-based hand sanitizers, a new study from Australia suggests.
The study focused on a bacterium called Enterococcus faecium, which is already resistant to some antibiotics and is a leading cause of hospital-acquired infections, such as urinary tract infections and sepsis. In fact, infections with drug-resistant E. faecium have been increasing in recent years, despite the growing use of hand sanitizers in hospitals, the researchers said.
The study found that over a nearly 20-year period, strains of E. faecium became better able to withstand alco-hol-based hand sanitizer, meaning the sanitizer didn’t kill the bacteria as well as it had before.
Still, the findings don’t mean that hospitals should ditch the hand sanitizer. “Alcohol-[based] hand-hygiene programs have been highly successful, particularly at controlling MRSA [methicillin-resistant Staphylococcus aureus], but also other types of hospital infections, and I would strongly advocate that we continue” using hand sanitizer, study co-author Dr. Paul Johnson, an infectious diseases professor at Austin Health in Victoria, Australia, said in a video about the study findings.
But to control certain pathogens, such as drug-resistant E. faecium, hospitals may need to add new measures, such as the use of other disinfectants, perhaps chlorine-based ones, the researchers said.
For the study, the researchers analyzed 139 samples of E. faecium bacteria collected between 1997 and 2015 from two hospitals in Melbourne.
Samples collected after 2010 were 10-fold more tolerant of alcohol-based sanitizers, compared with older samples, the researchers wrote in their paper, published Wednesday (Aug. 1) in the journal Science Translational Medicine.
The researchers analyzed DNA from the bacterial samples and found that the samples with more tolerance to hand sanitizers had several mutations in genes involved in metabolism. This resulted in increased resistance to alcohol.
The findings might explain the recent rise in drug-resistant E. faecium infections in hospitals, the researchers said.
Still, the researchers noted that because the study was conducted in only two Australian hospitals, more studies are needed to see if the same phenomenon

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