People with ‘rage’ disorder twice as likely to have toxoplasmosis


A disorder that causes the individual to fly off the handle unexpectedly, as in road rage, has been significantly linked with toxoplasmosis, a parasite commonly associated with cat feces, according to the Journal of Clinical Psychiatry.
People with IED are prone to sudden anger.
Intermittent explosive disorder (IED) has been defined as “recurrent, impulsive, problematic outbursts of verbal or physical aggression that are disproportionate to the situations that trigger them.”
Up to 16 million Americans are thought to have IED, more than the total number for bipolar disorder and schizophrenia combined.
Toxoplasmosis is a common and generally harmless parasitic infection that is passed on through the feces of infected cats, contaminated water or undercooked meat.
It affects around 30% of all humans but is normally latent1. Research has revealed that the parasite is found in brain tissue, and it has been linked to a number of psychiatric conditions, including schizophrenia, bipolar disorder and suicidal behavior.
Researchers from the University of Chicago, led by Dr. Emil Coccaro, have been looking for more effective ways to diagnose and treat IED and impulsive aggression. 22% of subjects with IED tested positive for the parasite
In the current study, the authors evaluated 358 adult Americans for IED, personality disorder, depression and other psychiatric disorders and gave them scores for traits such as anger, aggression and impulsivity. They also screened for toxoplasmosis using blood tests.
Fast facts about toxoplasmosis Around 60 million Americans are thought to have toxoplasmosis
If a woman catches it just before or during pregnancy, it can be dangerous for the baby For those with a weakened immune system, there are medications to treat it.
They then classified the participants into three groups: approximately one third had IED, one third were healthy controls with no psychiatric history, and one third had received a diagnosis for a psychiatric disorder but not IED.
The purpose of the last group was to enable the team to distinguish IED from other psychiatric factors. Findings showed that 22% of those with IED tested positive for toxoplasmosis exposure, compared with 9% of the healthy control group and 16% of the psychiatric control group.
The psychiatric group and the healthy group had similar scores for aggression and impulsivity, but the group with IED scored far higher on both counts than either of the other two groups.
An association emerged between toxoplasmosis and impulsivity.

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