Now there could be painkillers without danger


PAINKILLER addiction or abuse is a serious issue, which kills millions Prototype of a morphine-like molecule was able to bring pain relief Healthy tissues remained unaffected during the procedure
While health experts have preached about the ill-effects of pain killers umpteen times, sometimes you can’t help but depend on them to bring relief. Blame it on the times we live in, every other time one has to tackle some pain issues – headache, back pain, neck pain, stomach pain, the list goes on. Pain killers are said to be bad because they almost always come with side effects such as nausea, drowsiness, constipation, addiction, etc. They impact the opioid receptors in the brain, which prevent the release of neurotransmitters such dopamine, which is a chemical released by the neurons to send signals to other nerve cells. When this happens, the neurotransmitters flood the brain, creating the high and causing side effects.Painkiller addiction or abuse is a serious issue, which is said to kill millions of people worldwide. Those drugs must always be consumed under limited quantities, and only when required. Now thanks to a study done by researchers at an University in Berlin, they have found painkillers without dangerous side effects.
The researchers used computational simulation to analyze interactions at opioid receptors – the cell’s docking sites for painkillers. When used in an animal model, their prototype of a morphine-like molecule was able to produce substantial pain relief in inflamed tissues. However, healthy tissues remained unaffected, suggesting that the severe side effects currently associated with these types of painkillers might be avoided. The study was published in the journal Science, brain 620
There are different categories of painkillers, some mild and some strong, such as opioids. Strong painkillers are mainly used to treat pain associated with tissue damage and inflammation caused by surgery, nerve damage, arthritis or cancer. “By analyzing drug-opioid receptor interactions in damaged tissues, as opposed to healthy tissues, we were hoping to provide useful information for the design of new painkillers without harmful side effects,” explained Prof. Dr. Christoph Stein, Head of the Department of Anesthesiology and Surgical Critical Care Medicine on Campus Benjamin Franklin.
In cooperation with PD Dr. Marcus Weber from the Zuse Institute Berlin, and with the help of innovative computational simulations, the researchers were able to analyze morphine-like molecules and their interactions with opioid receptors.

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