Childhood poverty linked to brain changes related to depression


CHILDREN from poorer families are more likely to experience changes in brain connectivity that put them at higher risk of depression, compared with children from more affluent families. This is the conclusion of the new study by researchers from the Washington University School of Medicine in St. Louis, MO.
Researchers identified brain changes among children from low-income families that were associated with depression.
First study author Deanna M. Barch, PhD, chair of the Department of Psychological & Brain Sciences in Arts & Sciences, and colleagues publish their findings in The American Journal of Psychiatry.
The study builds on previous research from the team published last year, which found that children raised in poverty have reduced gray and white matter volumes in the brain, compared with those raised in richer families.
Additionally, they found that such brain changes were linked to poorer academic achievement.
For this latest study, the team set out to investigate whether childhood poverty may also lead to brain changes that influence mood and risk of depression, given that children raised in poorer families tend to be at higher risk of psychiatric illness and have worse cognitive and educational outcomes.
To reach their findings, Barch – also the Gregory B. Couch professor of psychiatry at Washington’s School of Medicine – and colleagues enrolled 105 preschool children aged 3-5.
The team calculated the poverty levels of the children using an income-to-needs ratio, which accounts for a family’s size and yearly income. At present, the federal poverty level in the US is $24,250 a year for a family of four.
Between the ages of 7-12, the children underwent functional magnetic resonance imaging (fMRI), which allowed the researchers to analyze the brain connections in the hippocampus – the region important for learning, memory and stress regulation – and the amygdala – a region associated with stress and emotion.
Compared with preschoolers from higher-income families, those from lower-income families demonstrated weaker connections between the left hippocampus and the right superior frontal cortex, as well as weaker connections between the right amygdala and the right lingual gyrus.
The researchers found that these weakened brain connections among preschool children raised in poverty were associated with greater risk of clinical depression at the age of 9 or 10.

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