WASHINGTON, Hollywood comedian Jerry Lewis, who died Sunday aged 91, perfected a goofy brand of slapstick that endeared him to millions over the course of a career spanning six decades. One of the most popular American entertainers of the 1950s and ’60s, Lewis made his name as the clown behind such quirky comedies as “The Nutty Professor” but also won acclaim as a writer, actor and philanthropist. The comedy legend, who at the peak of his popularity was among the world’s biggest movie draws, died at his home in Las Vegas early Sunday morning. “I can sadly confirm that today the world lost one of the most significant human beings,” said his publicist Nancy Kane. “Jerry died peacefully at home of natural causes surrounded by family and friends.” Fans left flowers at the comedian’s two stars on the Hollywood Walk of Fame. Honored with accolades at home and abroad, including a Nobel Peace Prize nomination and France’s Legion of Honor, Lewis became known as much for his tireless efforts to promote awareness of Muscular Dystrophy as for his wacky comedy. Over the course of 45 years, he raised some $2.45 billion for combatting the disease with an annual television event.