About-Face on ‘Obesity Paradox’: Extra Fat Does Raise Risk of Death

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THE findings contradict the so-called “obesity paradox,” a phenomenon seen in previous studies in which overweight people seemed to have a reduced risk of early death compared to those who were of normal weight.
But these prior studies relied on weight measurements at a single point in time, which meant the studies couldn’t determine if being overweight was really protective against early death, or if a lower weight was a signal that a person was sick and near death. The new study found that when researchers looked at people’s weight over many years, the obesity paradox was reversed.
The new finding is “important from a public health perspective, given that about one-third of adults in the U.S. and more than a quarter of the world’s population is overweight,” study author Edward Yu, a graduate student at the Harvard T.H Chan School of Public Health in Boston, said in a statement. “This is more reason why people should follow a healthy lifestyle and try to keep a normal weight,” Yu said.
The study analyzed information from more than 225,000 U.S. adults who took part in three large studies. Every two years, participants were surveyed on their body weight, health problems, smoking habits, physical activity and diet.
The researchers used information on participants’ height and weight to calculate their body mass index (BMI) over a 16-year period, then determined their highest or “maximum” BMI during this period. The participants were followed for another 12 years, on average. (At the start of this 12-year follow-up period, most participants were in their 50s or 60s.)
During the follow-up period, more than 32,500 participants died. Those who had a maximum BMI in the overweight range (from 25.0 to 29.9) were 6 percent more likely to die during the follow-up period compared with those who had a maximum BMI in the normal weight range (from 18.5 to 24.9).
What’s more, those who had a maximum BMI in the obese range (from 30 to 34.9) or severely obese range (35 or above) were 24 percent to 70 percent more likely to die during the follow-up period, compared to those in the normal weight range.
“The obesity paradox has always been something that we’ve questioned,” said Dr. Vincent Pera, director of weight management at the Miriam Hospital in Providence, Rhode Island, who was not involved in the new study.
This new research has a number of strengths over prior studies, including that it gathered data on participants’ weight throughout the study and didn’t ask participants to think back to what they weighed at some point in the past, Pera said. As a result, the authors were able to make their conclusion in a valid way, Pera said.